(Pyr11)-Amyloid β-Protein (11-40)

CompanySerial Number：DC160046(46)

ProductName：(Pyr11)-Amyloid β-Protein(11-40)

Synonym：

CASNo.：[192377-94-9]

Sequence(three-letter)：Pyr-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

Sequence(one-letter)： Pyr-VHHQKLVFFAEDVGSNKGAIIGLMVGGVV-OH

ConstitutionalFormula：

MolecularFormula： C143H226N38O39S

MolecularWeight：3133.67

References： C.Russoet al., FEBS Lett., 409, 411 (1997)
W.He and C.J.Barrow, Biochemistry, 38, 10871 (1999)
S.S.Mok et al., J. Neurosci. Res., 61, 449 (2000)
M.D.Kirkitadze et al., J. Mol. Biol., 312, 1103 (2001)

Illustration：ThisN-terminally truncated isoform of the amyloid β-protein (Aβ) beginning with apyroglutamate (Pyr) residue at position 11 was used in experiments studying thegenerality of fibrillogenesis-related helix formation. Comparing thefibrillogenesis kinetics of many of the most important clinically relevantamyloid β-protein alloforms it could be observed that among these peptides(Pyr11)-amyloid β-protein (11-40) exhibited the greatest retardation offibrillization rate.

ConditionOf Storage: -20± 5 °C