Acetyl-(Pro18,Asp21)-Amyloid β-Protein  (17-21) amide

Company Serial Number：DC160056(56)

Product Name：Acetyl-(Pro18,Asp21)-Amyloid  β-Protein (17-21) amide

Synonym： Ac-LPFFD-NH2

CAS No.：[339990-02-2]

Sequence(three-letter)：Ac-Leu-Pro-Phe-Phe-Asp-NH2

Sequence(one-letter)： Ac-LPFFD-NH2

Constitutional Formula：\Amyloid Peptides\68.png

Molecular Formula： C35H46N6O8

Molecular Weight：

References： B.Permanne et al., FASEB J., 16, 860 (2002)
 C.Adessi et al., J. Biol. Chem., 278, 13905 (2003)
 M.A.Chacon et al., Mol. Psychiatry, 9, 953 (2004)
 G.Vittelio et al., J. Pept. Sci., 16, 115 (2010)

Illustration：Ac-LPFFD-NH2  is an analog of product H-4876 with small chemical modifications which  enhance its stability against proteolytic degradation. It acts as a β-sheet  breaker peptide and crosses the blood-brain barrier at a higher rate than  most proteins and peptides known to be selectively taken up by the brain so  that it is assumed that the peptide is being specifically transported to the  brain. A significant increase in neuronal survival and decrease in brain  inflammation associated with the reduction of amyloid plaques in two  different transgenic Alzheimer`s disease (AD) models is additionally reported  for this pentapeptide.

Condition Of Storage: -20 ± 5 °C

★ 本产品仅供研发使用，不能用于人体