ent-[Amyloid β-Protein  (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])

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Product Name：ent-[Amyloid  β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)])

Synonym： ent-[retro-Amyloid β-Protein (16-20)]-β-Ala-D-Lys(ent-[Amyloid  β-Protein (16-20)]), (ffvlk)2(βA)k (tandem dimer)

CAS No.：[153247-40-6]  net

Sequence(three-letter)：H-D-Phe-D-Phe-D-Val-D-Leu-D-Lys-β-Ala-D-Lys(D-Lys-D-Leu-D-Val-D-Phe-D-Phe-H)-OH  Trifluoroacetate salt

Sequence(one-letter)： D-F-D-F-D-V-D-L-D-K-β-A-D-Lys(D-K-D-L-D-V-D-F-D-F-H)-OHTrifluoroacetatesalt

Constitutional Formula：

Molecular Formula： C79H119N15O13

Molecular Weight：1486.91

References： G.Zhang et al., Bioconjugate Chem., 14, 86 (2003)

Illustration：This  peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682)  corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer  retro-inverso peptide showed about a 100-fold higher binding affinity (Kd =  1.3 • 10-2 µM) for amyloid β-protein 1-40 fibrils than KLVFF (Kd = 1.1 ± 0.3  µM). It was also found to be more effective in preventing ordered fibril  formation than the parent peptide KLVFF as judged by its increased ability to  inhibit thioflavin T binding to β-sheet structures.

Condition Of Storage: -20 ± 5 °C

★ 本产品仅供研发使用，不能用于人体