(Lys22)-Amyloid β-Protein (1-40)

CompanySerial Number：DC160032(32)

ProductName：(Lys22)-Amyloid β-Protein(1-40)

Synonym： Amyloidβ-Protein (1-40) Italian Mutation, Amyloid β-Protein (1-40) E22K

CASNo.：[302905-01-7] net

Sequence(three-letter)：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter)： DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula：

MolecularFormula： C195H300N54O56S

MolecularWeight：4328.92

References： S.Tsubukiet al., Lancet, 351, 1957 (2003)
L.Morelli et al., J. Biol. Chem., 278, 23221 (2003)
Y.Masuda et al., Bioorg. Med. Chem., 13, 6803 (2005)
V.Betts et al., Neurobiol. Dis., 31, 442 (2008)

Illustration：TheItalian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the"wild-type" sequence 1-40. It showed increased neurotoxicity, which(according to a solid-phase NMR-study of Masuda et al.) may be due to the saltbridge formed between Lys22 and Asp23 in the minor conformer. As the Arctic,Flemish, and Dutch mutants, the Italian mutant is degraded considerably moreslowly than wild-type Aβ by neprilysin.

ConditionOf Storage: -20± 5 °C

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