(Gln22)-Amyloid β-Protein (1-40)

CompanySerial Number：DC160029(29)

ProductName：(Gln22)-Amyloid β-Protein(1-40)

Synonym： Amyloidβ-Protein (1-40) Dutch Mutation, Amyloid β-Protein (1-40) E22Q

CASNo.：[144410-00-4] net

Sequence(three-letter)：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Gln-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OHTrifluoroacetate salt

Sequence(one-letter)： DAEFRHDSGYEVHHQKLVFFAQDVGSNKGAIIGLMVGGVV-OHTrifluoroacetatesalt

ConstitutionalFormula：

MolecularFormula： C194H296N54O57S

MolecularWeight：4328.88

References： A.K.Sianet al., Biochem. J., 349, 299 (2000)
L.Miravalle et al., J. Biol. Chem., 275, 27110 (2000)

Z.Wanget al., Stroke, 31, 534 (2000)
S.Kumar-Singh et al., Neurobiol. Dis., 11, 330 (2002)
F.J.Mu?oz et al., J. Neurosci., 22, 3081 (2002)
R.Solito et al., Exp. Cell Res., 315, 385 (2009)
A.Jan et al., Nat. Protoc., 5, 1186 (2010)

Illustration：TheDutch mutation (E22Q) of amyloid β-peptide aggegates more readily than thewild-type peptide and the resulting fibrils show increased neurotoxicity. Themutant peptide E22Q induced apoptosis of cerebral endothelial cells at aconcentration of 25 μm, whereas WT Aβ (1-40) and the Italian mutant E22K(H-6698) showed no effect.

ConditionOf Storage: -20± 5 °C

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